Dietary vitamin K intake and anticoagulation in elderly patients

  title={Dietary vitamin K intake and anticoagulation in elderly patients},
  author={Luis Eduardo P Rohde and Michelli Cristina Silva de Assis and Eneida Rejane Rabelo},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
Purpose of reviewVitamin K is an essential co-factor for the synthesis of several coagulation factors. Oral anticoagulants competitively inhibit enzymes that participate in vitamin K metabolism. The purpose of this review is to evaluate the potential interaction of dietary vitamin K and coagulation stability, particularly in the elderly patient. Recent findingsRecent prospective evidences suggest that dietary vitamin K plays an essential role in anticoagulation stability. Vitamin K intake of… 

Dietary vitamin K intake and stability of anticoagulation with coumarins: evidence derived from a clinical trial.

The findings suggest that INR stability could be achieved with relatively low amounts of dietary vitamin K, which is significantly lower than that for unstable patients.

Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy: A Randomized Controlled Trial

A vitamin K–guided management strategy to adjust long-term oral anticoagulation is feasible and safe and may result in an increased chance of reaching target levels of INR.

Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?

Findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy and appears to be effective for those patients who are under-anticoagulated and consume a small number of vitamin K-rich food sources.

Vitamin K in parenteral nutrition.

The only unequivocal deficiency outcome is a bleeding syndrome caused by an inability to synthesize active coagulation factors II, VII, IX, and X, although there is growing evidence for roles for vitamin K in bone and vascular health.

Influence of VKORC1 gene polymorphisms on the effect of oral vitamin K supplementation in over-anticoagulated patients

The study indicated that the VKORC1 −1639G>A polymorphism plays a role in the response to acute vitamin K supplementation in over-anticoagulated patients, with faster decrease of INR value in patients carrying the G allele.


Warfarin (Coumadin and Marevan) is an extensively used anticoagulant drug used for treatment and prophylaxis of thromboembolic events in conditions such as atrial fibrillation, deep vein thrombosis,

Vitamin K for improved anticoagulation control in patients receiving warfarin.

This study found that in the group of participants deemed to have poor INR control, the addition of 150 micrograms (mcg) oral vitamin K significantly improved anticoagulation control in those with unexplained instability of response to warfarin.

Oral anticoagulant treatment and risk for bone fractures in uremic hemodialysed patients

The number of patients who received oral anticoagulants and the number of them who presented with bone fracture raises the suspicion that there is an association between anticoaggulant treatments and bone fractures.

Erratum to: Nutritional management of a patient with obesity and pulmonary embolism: a case report

In patients taking warfarin, evidence suggest that the aim of nutritional therapy should be to keep dietary intake of vitamin K constant, and the need for a change in the dietary approach of nutritional Therapy in the management of Vitamin K anticoagulant therapy is highlighted.



Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.

A diet is reported that provides a stable intake of vitamin K1 equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography.

Vitamin K and oral anticoagulation: thought for food.

Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects.

It is concluded that short-term variability in intake of K(1) is less important to fluctuations in the international normalized ratio (INR) than has been commonly assumed and that food supplements providing 100 microg/day of vitamin K( 1) do not significantly interfere with oral anticoagulant therapy.

Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation.

Daily supplementation with oral vitamin K in unstable patients could lead to a more stable anticoagulation response to warfarin.

Vitamin K intake and sensitivity to warfarin in patients consuming regular diets.

It is concluded that in 32% (16/50) of anticoagulated patients under usual dietary conditions sensitivity to warfarin is decreased by vitamin K intake > or =250 microg/day.

Dietary vitamin K influences intra‐individual variability in anticoagulant response to warfarin

A consistent intake of vitamin K could reduce intrapatient variability in anticoagulation response and thus improve the safety of warfarin therapy.

Controlled vitamin K content diet for improving the management of poorly controlled anticoagulated patients: a clinical practice proposal.

The data suggest that a diet with a controlled vitamin K content is effective in increasing the percentage of tests within the therapeutic range in patients with poorly controlled anticoagulation.

Interaction of dietary factors with oral anticoagulants: review and applications.

  • J. E. Harris
  • Medicine
    Journal of the American Dietetic Association
  • 1995

Acquired warfarin resistance and weight-reducing diet.

It is concluded that in patients on vegetable-rich, weight-reducing diets, a relative resistance to warfarin may be secondary to their increased dietary intake of vitamin K.