Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate.

@article{Kovalenko2011DietaryVD,
  title={Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate.},
  author={Pavlo L. Kovalenko and Zhentao Zhang and Jun-Ge Yu and Yan Li and Steven K. Clinton and James C. Fleet},
  journal={Cancer prevention research},
  year={2011},
  volume={4 10},
  pages={1617-25}
}
Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest. We tested whether low VD status or VD receptor (VDR) deletion influences prostate epithelial cell (PEC) biology using intact mice, castrated mice, or castrated mice treated with testosterone propionate (TP, 2.5 mg/kg BW). PEC proliferation (Ki-67 staining) and apoptosis (TUNEL method) were determined in the anterior prostate (AP). In study 1, wild-type (WT) and TgAPT(121) mice… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level Kovalenko et al

  • PL Kovalenko, Z Zhang, M Cui, SK Clinton, JC. Fleet
  • Cancer Prev Res;
  • 2011
Highly Influential
9 Excerpts

A systematic review and meta-analysis of bone metabolism in prostate adenocarcinoma

  • NA Serpa, M Tobias-Machado, MA Esteves, MD Senra, ML Wroclawski, FL Fonseca
  • BMC Urol
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…