Dietary vitamin C supplementation lowers blood pressure in spontaneously hypertensive rats

@article{Vasdev2001DietaryVC,
  title={Dietary vitamin C supplementation lowers blood pressure in spontaneously hypertensive rats},
  author={Sudesh C. Vasdev and Carol Ann Ford and Sushil Parai and Linda Longerich and Veeresh Gadag},
  journal={Molecular and Cellular Biochemistry},
  year={2001},
  volume={218},
  pages={97-103}
}
In spontaneously hypertensive rats (SHRs) excess endogenous aldehydes bind sulfhydryl groups of membrane proteins, altering membrane Ca2+ channels and increasing cytosolic free calcium and blood pressure. The thiol compound, N-acetyl cysteine, normalizes elevated blood pressure in SHRs by binding excess endogenous aldehydes. Vitamin C can increase tissue cysteine and glutathione levels. The aim of the present study was to investigate whether a dietary supplementation of vitamin C can lower… CONTINUE READING
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Role of endogenous aldehydes in spontaneously hypertensive and disulfiram-induced hypertensive rats

  • S Vasdev, T Mian, CA Ford, L Longerich, S Parai
  • Nutr Metab Cardiovasc Dis
  • 1996
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