Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver

@article{Rasooly2007DietaryT1,
  title={Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver},
  author={Reuven Rasooly and Darshan Singh Kelley and Jeff Greg and Bruce E. Mackey},
  journal={British Journal of Nutrition},
  year={2007},
  volume={97},
  pages={58 - 66}
}
Mice fed diets containing trans 10, cis 12 (t10, c12)-conjugated linoleic acid (CLA) develop fatty livers and the role of hepatic fatty acid oxidation enzymes in this development is not well defined. We examined the effects of dietary cis 9, trans 11-CLA (c9, t11-CLA) and t10, c12-CLA on the expression of hepatic genes for fatty acid metabolism. Female mice, 8 weeks old, (six animals per group) were fed either a control diet or diets supplemented with 0·5 % c9, t11- or t10, c12-CLA for 8 weeks… 
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Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.
Hepatomegaly Induced by Trans-10,cis-12 Conjugated Linoleic Acid in Adult Hamsters Fed an Atherogenic Diet Is Not Associated with Steatosis
TLDR
The results show that the expected body fat-lowering effect of trans-10,cis-12 CLA, observed in young rodents, is not found in adult hamsters, and the lack of increase in liver fatty acid oxidation, help to explain why that effect wasNot found in these animals.
Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose of Trans-10, cis-12-Conjugated Linoleic Acid
TLDR
Results suggested that a chronic low dose of dietary CLA increases liver mass and lipid accumulation due to activation of lipogenesis and insufficient induction of LCFA oxidation and VLDL assembly/secretion.
Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue
TLDR
Results from this study underscored the role of PParγ signaling on mammary lipogenic target regulation and the proinflammatory effect due to CLA could be related to inhibition of PPARγ signaling.
Trans-10,cis-12-CLA-Caused Lipodystrophy Is Associated with Profound Changes of Fatty Acid Profiles of Liver, White Adipose Tissue and Erythrocytes in Mice: Possible Link to Tissue-Specific Alterations of Fatty Acid Desaturation
TLDR
A significant reduction of adipose tissue accompanied by fatty livers in the CLA-mix-fed group and profound changes in fatty acid composition of lipogenic organs due to t10,c12-CLA intake may be the consequence of function- al alterations of lipid metabolism.
Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation.
TLDR
Responsibility of different tissues to CLA and DHA varied; CLA was more potent than DHA in altering depot fat and insulin concentrations.
Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice.
Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression
TLDR
Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids from adipose tissue and the liver's inability to sufficiently increase FA oxidation and export of synthesized triglycerides.
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
TLDR
It is shown that expression of these genes is highly associated with hepatic steatosis in a genetic disease such as Cbs deficiency and in two common situations such as Western diets containing CLA isomers or a Mediterranean-type diet.
Gene expression after dietary intervention with trans fatty acids (trans-11/trans-12 18:1) in humans
TLDR
Gender- and treatment-related gene expression was found during the intervention with two trans fatty acids and endogenous CLA from trans-11 18:1 as precursor in humans and a clear increase in gene expression of PPARg and GLUT4 was shown.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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