Dietary supplementation: effects on visual performance and occurrence of AMD and cataracts

  title={Dietary supplementation: effects on visual performance and occurrence of AMD and cataracts},
  author={Felix M. Barker},
  journal={Current Medical Research and Opinion},
  pages={2011 - 2023}
  • F. M. Barker
  • Published 15 July 2010
  • Medicine
  • Current Medical Research and Opinion
Abstract Objective: To evaluate results of studies that have provided information regarding the effects of dietary supplementation on visual performance, development and progression of age-related macular degeneration (AMD), and risk for cataracts. Research design and methods: Studies with information about the effects of dietary supplementation were identified via PubMed searches that combined (in separate searches) the terms ‘supplement’ OR ‘supplementation’ OR ‘diet’ AND ‘cataract’ or… 

Optimising dietary modification for age-related macular degeneration (AMD)

A body of research adds insights into dietary interventions within visually impaired groups, studies embedded may enrich dietary advice in the context of AMD, and ready meals were created as a novel intervention to improve diet in this population.

Antioxidant vitamins, minerals and cataract: current opinion

It is not clear that antioxidant vitamins and minerals nor that healthy diets prevent the development and progression of cataract, and a combination of antioxidant vitamins such as vitamins C and E may have a synergistic effect onCataract prevention.

The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases

There are increasing evidences that L and Z may also improve normal ocular function by enhancing contrast sensitivity and by reducing glare disability, and the appropriate consumption quantities, the consumption safety of L, side effects and future research directions are discussed.

The Role of Lutein in Eye-Related Disease

The role of lutein and zeaxanthin in ameliorating light and oxygen damage, and preventing age-related cellular and tissue deterioration in the eye is discussed, and possible role of nutritional intervention in common ocular diseases that cause blindness is offered.

Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?

In these animal models, lutein and zeaxanthin have been reported to have beneficial effects in protecting ocular tissues and cells against damage caused by different etiological factors, including prevention of phototoxic damage by absorption of blue light, reduction of oxidative stress through antioxidant activity and free radical scavenging, and their anti-inflammatory and antiangiogenic properties.

Macular Pigment Optical Density and Its Relationship with Refractive Status and Foveal Thickness in Chinese School-aged Children

Macular pigment optical density was inversely related to MFT and positively related to CFT in Chinese school-age children with low-to-moderate myopia and showed no significant association with age, BMI, IOP, SE or foveal thickness.

Long-term incidence of visual impairment in older persons: associated factors, burden and impacts

The association between diet quality and the incidence of VI, and associations between VI and the subsequent use of support services, subsequent events of falls, fractures, depressive symptoms, and cognitive decline over the short(5 years) and long-terms (10+ years).

Lens protein glycation in diabetic and senile cataract patients

The level of lens glycated protein was found to be significantly increased in subjects of type 2 diabetes mellitus compared to senile cataracts, indicating that glycation of lens protein may play an important role in the development of cataract with greater extent in diabetic patients compared tosenile group.

Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study

  • C. DaniI. Lori Cristiana Germini
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2012
L/Z supplementation was ineffective in preventing ROP in preterm infants and did not affect the outcome at discharge of the authors' patients.



Age-related macular degeneration and antioxidant vitamins: recent findings

Findings on the association of certain antioxidants and docosahexaenoic acid support a role for nutrition in a decreased risk of AMD and the inconsistent findings of an increased risk with increased intake of β-carotene and vitamin E warrants continued investigation into these relationships.

Nutrition and the prevention of cataracts

High doses of multivitamins, antioxidants, or lutein and zeaxanthin are unlikely to be of significant ophthalmic benefit to the general public, but these nutrients may help individuals exposed to high oxidative stress and those with poor nutrition.

TOZAL Study: An open case control study of an oral antioxidant and omega-3 supplement for dry AMD

Treatment with this unique nutritional supplement increased VA above the expected baseline decrease in the majority of patients in this population with dry macular degeneration, and the results of the TOZAL study agree with the LAST and CARMIS studies and are predictive for positive visual acuity outcomes in the AREDS II trial.

Macular pigment: influences on visual acuity and visibility

An ideal ocular nutritional supplement? *

  • H. BartlettF. Eperjesi
  • Medicine
    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians
  • 2004
Vitamins C and E, and lutein/zeaxanthin should be included in the theoretically ideal ocular nutritional supplement, suitable for those with a family history of glaucoma, cataract, or age‐related macular disease, or lifestyle factors predisposing onset of these conditions, such as smoking, poor nutritional status, or high levels of sunlight exposure.

Vitamin E supplementation and macular degeneration: randomised controlled trial

Daily supplement with vitamin E supplement does not prevent the development or progression of early or later stages of age related macular degeneration.

The Linxian cataract studies. Two nutrition intervention trials.

Findings from the two trials suggest that vitamin/mineral supplements may decrease the risk of nuclear cataract.

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.