Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3

@inproceedings{Kim2015DietarySP,
  title={Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3},
  author={Jung Hyun Kim and Thomas P Neufeld},
  booktitle={Nature communications},
  year={2015}
}
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin release is tightly regulated in response to dietary conditions, but how insulin-producing cells (IPCs) coordinate their responses to distinct nutrient signals is unclear. Here we show that regulation of insulin secretion in Drosophila larvae has been segregated into distinct branches-whereas amino acids promote the secretion of Drosophila insulin-like peptide 2 (Dilp2), circulating sugars promote… CONTINUE READING
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