Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance.

  title={Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance.},
  author={Haim Mayan and King-Hwa Ling and Eun Young Lee and Eckehart Wiedemann and Judith E. Kalinyak and Michael H. Humphreys},
  volume={28 2},
The pituitary prohormone proopiomelanocortin gives rise to melanocortins of alpha, beta, and gamma primary structure in addition to corticotropin. Melanocortins have a variety of actions in mammals, and each is natriuretic. In particular, gamma-melanocyte-stimulating hormone has been shown to mediate reflex natriuresis after acute unilateral nephrectomy. We examined whether this peptide could play a role in longer term adjustments in sodium balance by measuring plasma gamma-melanocyte… CONTINUE READING