Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet.

@article{Frassetto2007DietarySC,
  title={Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet.},
  author={Lynda Ann Frassetto and Robert C. Morris and Anthony Sebastian},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 2},
  pages={F521-5}
}
We previously demonstrated that typical American net acid-producing diets predict a low-grade metabolic acidosis of severity proportional to the diet net acid load as indexed by the steady-state renal net acid excretion rate (NAE). We now investigate whether a sodium (Na) chloride (Cl) containing diet likewise associates with a low-grade metabolic acidosis of severity proportional to the sodium chloride content of the diet as indexed by the steady-state Na and Cl excretion rates. In the steady… CONTINUE READING
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