Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

@article{Zhu1999DietaryRP,
  title={Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation},
  author={H. Zhu and Q Guo and Mark P. Mattson},
  journal={Brain Research},
  year={1999},
  volume={842},
  pages={224-229}
}
Alzheimer's disease (AD) is an age-related disorder that involves degeneration of synapses and neurons in brain regions involved in learning and memory processes. Some cases of AD are caused by mutations in presenilin-1 (PS1), an integral membrane protein located in the endoplasmic reticulum. Previous studies have shown that PS1 mutations increase neuronal vulnerability to excitotoxicity and apoptosis. Although dietary restriction (DR) can increase lifespan and reduce the incidence of several… CONTINUE READING

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