Dietary restriction of calcium, phosphorus, and vitamin D elicits differential regulation of the mrnas for avian intestinal calbindin‐D28K and the 1,25‐dihydroxyvitamin D3 receptor

@article{Meyer1992DietaryRO,
  title={Dietary restriction of calcium, phosphorus, and vitamin D elicits differential regulation of the mrnas for avian intestinal calbindin‐D28K and the 1,25‐dihydroxyvitamin D3 receptor},
  author={J Meyer and C. S. Fullmer and Robert H. Wasserman and Barry S. Komm and Mark R. Haussler},
  journal={Journal of Bone and Mineral Research},
  year={1992},
  volume={7}
}
We investigated the regulation of 1,25‐dihydroxyvitamin D3 [1,25‐(OH)2D3]‐induced calbindin‐D28k (CaBP) and of the vitamin D receptor (VDR) by evaluating CaBP protein, CaBP mRNA, and VDR mRNA under conditions of altered intake of vitamin D, calcium, or phosphorus. Chickens were maintained for 10 days on one of four diets: vitamin D‐deficient, normal (1.0% Ca and 1.1% P), low calcium (0.1% Ca and 1.2% P), and low phosphorus (1.1% Ca and 0.3% P). CaBP was undetectable in D‐deficient duodena and… Expand
Effects of vitamin D, dietary calcium and vitamin D restriction, pregnancy and lactation on gene expression of calcium transporting factors
TLDR
Results of Northern blotting of duodenal tissues indicated that a single injection of 20 ng of 1,25-dihydroxyvitamin D3 per rat doubled intestinal PMCAl at 4, 8, and 12 hours after injection, and CaBP-9K mRNA was increased at 8, 12, and 24Hours after injection. Expand
Regulation of renal vitamin D receptor is an important determinant of 1alpha,25-dihydroxyvitamin D(3) levels in vivo.
TLDR
It appears that tissue-specific down-regulation of VDR by hypocalcemia blocks the 1,25-(OH)(2)D(3) suppression of the 1alpha-OHase and upregulation of the 24- OHase in the kidney, causing a marked accumulation of 1, 25-(OH)*2(3), which rises to high levels at the high vitamin D dose levels. Expand
Tissue specificity and mechanism of vitamin D receptor up‐regulation during dietary phosphorus restriction in the rat
TLDR
The results of these studies indicate that VDR up‐regulation during dietary phosphorus restriction is tissue‐specific and that the mechanism of the up-regulation is time‐dependent. Expand
Parathyroid hormone decreases renal vitamin D receptor expression in vivo.
TLDR
Results demonstrate that PTH is a potent down-regulator of VDR expression in vivo, and is an important factor in calcium homeostasis, vitamin D metabolism, and the treatment of secondary hyperparathyroidism and renal osteodystrophy. Expand
Molecular Mechanisms of Vitamin D Action
TLDR
Combined alternative VDR ligand(s) and 1,25D/VDR control of gene expression may delay chronic disorders of aging such as osteoporosis, type 2 diabetes, cardiovascular disease, and cancer. Expand
Association Between Intestinal Vitamin D Receptor, Calcium Absorption, and Serum 1,25 Dihydroxyvitamin D in Normal Young and Elderly Women
TLDR
The decrease in calcium absorption cannot be explained by a decrease in intestinal VDR, and the correlation between serum 1,25(OH)2D and both calcium absorption tests only accounts for 12–30% of the variance in the age‐related change in the calcium absorption Tests. Expand
Simultaneous Exposure of Excess Fluoride and Calcium Deficiency Alters VDR, CaR, and Calbindin D 9  k mRNA Levels in Rat Duodenal Mucosa
TLDR
It is concluded that excess fluoride reduces the mRNA levels of VDR and D 9  k in the duodenal mucosa of rats, thereby possibly reducing calcium absorption and calcium supplementation with simultaneous fluoride removal improves their expression. Expand
Age, phosphorus, and 25‐hydroxycholecalciferol regulate mRNA expression of vitamin D receptor and sodium‐phosphate cotransporter in the small intestine of broiler chickens
TLDR
Results showed that mRNA expression levels of nVDR and NaPi‐IIb were highest in the duodenum of 21‐day‐old broilers, lower in the jejunum, and lowest in the ileum, while age linearly decreased mRNA expression level of 1&agr;‐hydroxylase in kidneys. Expand
1,25(OH)2D3‐dependent regulation of calbindin‐D28k mRNA requires ongoing protein synthesis in chick duodenal organ culture
TLDR
It is proposed that a labile auxiliary protein or other cofactor is necessary for 1,25(OH)2D3‐mediated CaBP gene transcription in chick duodena, and is dependent on ongoing protein synthesis. Expand
The Caudal‐Related Homeodomain Protein Cdx‐2 Regulates Vitamin D Receptor Gene Expression in the Small Intestine
  • H. Yamamoto, K. Miyamoto, +6 authors E. Takeda
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1999
TLDR
It is demonstrated that Cdx‐2 is able to activate VDR gene transcription by binding to the sequence 5′‐ATAAAAACTTAT‐3′ at −3731 to −3720 bp relative to the transcription start site of the hVDR promoter. Expand
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References

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Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat.
TLDR
The results of this study indicate that under physiologic conditions as during chronic dietary calcium restriction, increased intestinal vitamin D receptor content accompanies increased calcium active transport. Expand
Effect of hormones and development on the expression of the rat 1,25-dihydroxyvitamin D3 receptor gene. Comparison with calbindin gene expression.
TLDR
The data indicate that in the adult rat, target tissue response to hormone is not modified by a corresponding alteration in new receptor synthesis, and it is demonstrated that glucocorticoid administration can result in an alteration in intestinal calbindin and VDR gene expression. Expand
Parathyroid hormone down-regulates 1,25-dihydroxyvitamin D receptors (VDR) and VDR messenger ribonucleic acid in vitro and blocks homologous up-regulation of VDR in vivo.
TLDR
The effect of PTH on VDR regulation in vitro in ROS 17/2.8 cells and in vivo in male Holtzman rats is examined to suggest that PTH is a potent down-regulator of VDR and that P TH and 1,25(OH)2D3 have opposing effects on the expression of certain genes. Expand
Contrasting effects of exogenous 1,25-dihydroxyvitamin D [1,25-(OH)2D] versus endogenous 1,25-(OH)2D, induced by dietary calcium restriction, on vitamin D receptors.
TLDR
Under physiological conditions, increased plasma concentrations of 1,25-(OH)2D do not result in up-regulation of tissue vitamin D receptor concentrations, and that dietary calcium restriction must induce some factor(s) that results in down- regulation of vitamin D receptors in the kidney. Expand
Effect of vitamin D status on the equilibrium between occupied and unoccupied 1,25-dihydroxyvitamin D intestinal receptors in the chick.
TLDR
The dynamic equilibrium between in vivo occupied and unoccupied 1,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)] receptors of the chick intestinal mucosa was investigated and there was a positive correlation between occupied receptor and CaBP levels. Expand
Modulation of chick intestinal and renal calbindin gene expression by dietary vitamin D3, 1,25-dihydroxyvitamin D3, calcium and phosphorus
TLDR
The results suggest that most of the changes in renal and intestinal calbindin could be attributed to theChanges in the mRNA; the adaptation to dietary Ca and P alterations requires vitamin D metabolites; and plasma Ca and renal cal bindin or its mRNA tend to change together in vitamin D-deficient or vitamin D3- fed, but not in 1,25(OH)2D3-fed chicks. Expand
Tissue-specific regulation of avian vitamin D-dependent calcium-binding protein 28-kDa mRNA by 1,25-dihydroxyvitamin D3.
TLDR
In vitamin D-deficient chicks, 28-kDa CaBP mRNA was virtually undetectable in intestine, was clearly detectable in kidney, and present at the highest levels in cerebellum, but after a single intravenous dose of 500 ng of 1,25-(OH)2D3, intestinal 28-KDa Ca BP mRNA levels were increased 50-fold, kidney levels wereincreased 4- fold, and cere Bellum levels were unchanged. Expand
Expression of calbindin-D28K mRNA as a function of altered serum calcium and phosphorus levels in vitamin D-replete chick intestine
TLDR
The data suggest that calcium and phosphorus regulation of CaBP occurs at a post-transcriptional level, and there was surprisingly no difference in steady-state CaBP mRNA levels between the different dietary groups. Expand
Effects of alpha-amanitin and cycloheximide on 1,25-dihydroxyvitamin D3-dependent calbindin-D28K and its mRNA in vitamin D3-replete chick intestine.
TLDR
Results indicate that continual protein synthesis is necessary for the expression of CaBP-mRNA, suggesting the existence of a rapidly turned over protein that may be required for stabilization or for processing of the chick intestinal CaBP messenger RNA. Expand
The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets.
TLDR
It is proposed that the intestine and the kidney, but not bone, are the main target organs for cholecalciferol in the maintenance of calcium homeostasis, and that both calcium and phosphorus play a role in the regulation of the formation and subsequent function of 1, 25-dihydroxycholecalcifierol. Expand
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