Dietary restriction modulates mitochondrial DNA damage and oxylipins profile in aged rats.

@article{Gureev2022DietaryRM,
  title={Dietary restriction modulates mitochondrial DNA damage and oxylipins profile in aged rats.},
  author={Artem P. Gureev and Nadezda V. Andrianova and Irina B Pevzner and Ljubava D. Zorova and Ekaterina V Chernyshova and Irina S. Sadovnikova and Dmitry V. Chistyakov and Vasily A. Popkov and D. S. Semenovich and Valentina A. Babenko and D. N. Silachev and Dmitry B. Zorov and Egor Yu Plotnikov and Vasily N. Popov},
  journal={The FEBS journal},
  year={2022}
}
Age-related impairment of coordination of the processes of maintaining mitochondrial homeostasis is associated with a decrease in the functionality of cells and leads to degenerative processes. Mitochondrial DNA (mtDNA) can be a marker of oxidative stress and tissue degeneration. However, the mechanism of accumulation of age-related damage in mtDNA remains unclear. In this study, we analyzed the accumulation of mtDNA damage in several organs of rats during aging, as well as the possibility of…