Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys.

@article{Kemnitz1994DietaryRI,
  title={Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys.},
  author={Joseph W. Kemnitz and Ellen B. Roecker and R. H. Weindruch and Diane F. Elson and Scott T. Baum and Richard N. Bergman},
  journal={The American journal of physiology},
  year={1994},
  volume={266 4 Pt 1},
  pages={
          E540-7
        }
}
Insulin sensitivity and glucose tolerance typically decline during later life. In a multidimensional randomized trial of the effects of dietary restriction started in adulthood on the processes of aging, we are studying insulin sensitivity and glucoregulation longitudinally in control (C, n = 15, fed a defined diet ad libitum for 6-8 h/day) and restricted (R, n = 15, fed 30% less than C) monkeys using the Modified Minimal Model method. Linear rates of change were calculated for individual… Expand
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr.
TLDR
Chronic DR not only has protected against the development of insulin resistance in aging rhesus monkeys, but has also improved glucoregulatory parameters compared with those of otherwise normoinsulinemic monkeys. Expand
Dietary restriction and beta-cell sensitivity to glucose in adult male rhesus monkeys.
TLDR
Indices of body fatness were highly predictive of the effect of DR on Ø (b), fasting insulin concentration and insulin responses to glucose, and Enhanced peripheral insulin sensitivity among R monkeys was strongly correlated with lower Ø(b). Expand
Insulin sensitivity and glucose effectiveness from three minimal models: effects of energy restriction and body fat in adult male rhesus monkeys.
TLDR
Precision of estimation and intermodel relationships among insulin sensitivity and glucose effectiveness estimates were in the ranges of those reported previously for humans and dogs, suggesting that the models may provide valid estimates for rhesus monkeys as well. Expand
Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys
TLDR
CR increases insulin sensitivity on a whole-body level and enhances insulin receptor signaling in this higher species and may alter insulin signaling in vivo by modulating protein content of insulin receptor signalling proteins. Expand
Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus
TLDR
It is suggested that both CR and RSV have beneficial effects on metabolic alterations, although these effects are different in amplitude between the two anti-aging treatments and potentially rely on different metabolic changes. Expand
Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
TLDR
It was found that theCR and EX volunteers were significantly leaner than the WD volunteers, and insulin sensitivity was significantly higher in the CR and EX groups than in the WD group, despite high serum adiponectin and low inflammation. Expand
Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs.
TLDR
Glucose disposal efficiency and insulin response were associated with increased quality and length of life in diet-restricted dogs, and diet restriction explained most of this relationship's variation. Expand
Brief food restriction in old animals decreases triglyceride content and insulin-stimulated triglyceride synthesis.
  • M. Tucker, L. Turcotte
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2005
TLDR
The results indicate that brief food restriction in old animals improves insulin sensitivity as it pertains to both glucose uptake and FA oxidation, and the decreased FA oxidation under hyperinsulinemic conditions may significantly contribute to food restriction-induced reduction in muscle TG. Expand
Effects of feed restriction and cold exposure on glucose metabolism in response to feeding and insulin in sheep.
TLDR
In sheep fed a roughage diet, blood glucose turnover rate seems to be influenced by both intake level and environmental temperature, but not by the act of feeding, while the action of insulin on glucose metabolism is enhanced during cold exposure, and the effect of feed restriction is somewhat enhanced. Expand
Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats.
TLDR
Findings indicate that 8 mo of CR did not cause a continuous reduction in in vivo glucose uptake by any tissue studied, and, in several insulin-sensitive tissues, glucose uptake was at times greater for CR vs. AL rats. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Plasma concentrations of glucose, insulin, and percent glycosylated hemoglobin are unaltered by food restriction in rhesus and squirrel monkeys.
TLDR
The results suggest possible differences in glucose-related metabolism in ad libitum and food-restricted primates as compared to observations made in rats. Expand
Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats
TLDR
The increased insulin responsiveness of R rats was not due to an increase in insulin binding or to a decrease in insulin degradation (measured with intact cells or as cytosolic insulinase activity), and is compatible with a delay in the first phase of insulin secretion in aging AL rats. Expand
Dietary restriction alters characteristics of glucose fuel use.
TLDR
Findings are consistent with the glycation hypothesis of aging and with the hypothesis that dietary restriction retards the aging processes by altering the characteristics of fuel use, but do not establish the validity of either. Expand
Effect of Age and Diet on Insulin Secretion and Insulin Action in the Rat
TLDR
The results suggest that aging leads to marked changes in both insulin secretion and insulin action, and the decline in glucose-stimulated insulin secretion per unit endocrine pancreas appears to be an inevitable consequence of the aging process. Expand
Obesity in male and female rhesus monkeys: fat distribution, glucoregulation, and serum androgen levels.
TLDR
It is concluded that obese male and female rhesus monkeys have patterns of fat distribution and glucoregulatory abnormalities similar to those of humans with upper body obesity. Expand
Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function.
TLDR
The studies suggest that the diminished glucose tolerance of aging in normal weight men has multifactorial causality, and both beta-cell dysfunction and insulin resistance are important. Expand
Dietary restriction and aging: the initiation of a primate study.
TLDR
Analysis of body weights among these respective control and experimental groups from the first year of the study indicated that the monkeys undergoing dietary restriction were gaining weight at a markedly slower rate compared to control values. Expand
Role of Insulin Resistance in Human Disease
TLDR
The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD. Expand
Insulin Resistance in Aging Is Related to Abdominal Obesity
TLDR
Insulin resistance is more closely associated with abdominal adiposity than with age, and measurements at most central body sites were significantly larger in the insulin-resistant older subjects. Expand
Characteristics of spontaneous obesity in male rhesus monkeys
TLDR
It is concluded that some adult male rhesus monkeys develop obesity without obvious differences in eating behavior and that obese monkeys, like obese humans, are at risk for diabetes mellitus and its complications. Expand
...
1
2
3
...