Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence.

@article{Weindruch1982DietaryRI,
  title={Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence.},
  author={R. H. Weindruch and Roy L. Walford},
  journal={Science},
  year={1982},
  volume={215 4538},
  pages={
          1415-8
        }
}
Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without… 
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742 Citations

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16 References

Influence of controlled dietary restriction on immunologic function and aging.

Mounting evidence indicates that underfeeding initiated later in life may also influence life span favorably, and the immunologic effects of underfeeding, when measured quite early in life, are strain-dependent in the mouse.

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Length of life and caloric intake.

  • M. H. Ross
  • Medicine
    The American journal of clinical nutrition
  • 1972
It is demonstrated that a dietary regimen maintained for a relatively short period of time early in life has long lasting effects in that it ultimately influences life expectancy patterns of the population, and that the level of caloric restriction most conducive to an increase in length of life changes with age.

Nutritional probe of the aging process.

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Survival and disease patterns in C57BL/6J mice subjected to undernutrition

Tumor incidence patterns and nutrition in the rat.

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Mortality and growth characteristics of rat strains commonly used in aging research.

  • E. Masoro
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    Experimental aging research
  • 1980
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The penicillin made no difference to the final concentration gradients of D-glucose or L-histidine achieved by rat small intestine, although with the hamster these appeared somewhat improved, and water entry into the serosal fluid remained unchanged.