Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence.

@article{Weindruch1982DietaryRI,
  title={Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence.},
  author={R. H. Weindruch and Roy L. Walford},
  journal={Science},
  year={1982},
  volume={215 4538},
  pages={
          1415-8
        }
}
Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without… 

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Beneficial Biochemical Outcomes of Late‐Onset Dietary Restriction in Rodents

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Effect of caloric restriction on age-associated cancers

Effects of germfree status and food restriction on longevity and growth of mice.

The GF mice survived longer than the SPF mice, but the combination of GF status with food restriction did not seem to extend life span more than food restriction alone.

Potential Role of the Modulation of Fuel Use in the Antiaging Action of Dietary Restriction

  • E. Masoro
  • Biology, Medicine
    Annals of the New York Academy of Sciences
  • 1992
Mortality data provide strong evidence in support of the view that dietary restriction retards the aging process, and dietary restriction has robust effects on the physiological systems and on disease processes, further supporting this conclusion.
...

References

SHOWING 1-10 OF 16 REFERENCES

Influence of controlled dietary restriction on immunologic function and aging.

Mounting evidence indicates that underfeeding initiated later in life may also influence life span favorably, and the immunologic effects of underfeeding, when measured quite early in life, are strain-dependent in the mouse.

Length of life and caloric intake.

  • M. H. Ross
  • Medicine
    The American journal of clinical nutrition
  • 1972
It is demonstrated that a dietary regimen maintained for a relatively short period of time early in life has long lasting effects in that it ultimately influences life expectancy patterns of the population, and that the level of caloric restriction most conducive to an increase in length of life changes with age.

Nutritional probe of the aging process.

These studies provide a start in analyzing the mechanisms by which food restriction prolongs life and delays disease and it is to be anticipated that future research along this line will not only further define these mechanisms but in addition should greatly contribute to the knowledge of the aging process.

Tumor incidence patterns and nutrition in the rat.

Length of life was influenced not only by the degree of dietary restric tion but also by change in the ratio of the protein and carbohydrate components of the diets, and the shortest life expect ancy was observed to be associated with the highest incidence of glomerulonephroJ.

Suppression of adenocarcinoma by the immunological consequences of calorie restriction

Observations on the influence of calorie restriction on development of spontaneous mammary adenocarcinoma in mice are presented and the suppression of tumour development observed is related to alterations in immune functions produced by calorie restriction at weaning.

Ageing and the Regulation of Cell Activities during Exposure to Cold

These experiments provide an example of an age change in a gene-dependent cell process (the delayed induction of TAT in senescent mice during exposure to cold) which is not due to a change in the potential of the genome for responding when exogenous stimulae are supplied (injection of hormones).

Mortality and growth characteristics of rat strains commonly used in aging research.

  • E. Masoro
  • Biology
    Experimental aging research
  • 1980
This review aims to provide available data on the mortality and growth characteristics of rat strains commonly used in aging research and the influences of nutrition and housing conditions on these characteristics.

Studies on the active transport of D-glucose and L-histidine by rats and golden hamsters fed on a penicillin-enriched diet

The penicillin made no difference to the final concentration gradients of D-glucose or L-histidine achieved by rat small intestine, although with the hamster these appeared somewhat improved, and water entry into the serosal fluid remained unchanged.