Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

@inproceedings{Tang2016DietaryRI,
  title={Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging},
  author={Duozhuang Tang and Si Lu Tao and Zhiyang Chen and Ievgen Oleksandrovich Koliesnik and Philip Gerald Calmes and Verena Hoerr and Bing Han and Nadja Gebert and Martin Z{\"o}rnig and Bettina Loeffler and Yohei Morita and Karl Lenhard Rudolph},
  booktitle={The Journal of experimental medicine},
  year={2016}
}
Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman primates revealed ambiguous effects of DR on lifespan despite improvements in health parameters. In this study, we analyzed consequences of adult-onset DR (24 h to 1 yr) on hematopoietic stem cell (HSC) function. DR ameliorated HSC aging phenotypes, such as the increase in number of HSCs and the skewing toward myeloid-biased HSCs during aging… CONTINUE READING
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