Dietary rescue of fumble—a Drosophila model for pantothenate-kinase-associated neurodegeneration

@article{Yang2005DietaryRO,
  title={Dietary rescue of fumble—a Drosophila model for pantothenate-kinase-associated neurodegeneration},
  author={Yan-ling Yang and Zhi-ying Wu and Yien Ming Kuo and Bing Zhou},
  journal={Journal of Inherited Metabolic Disease},
  year={2005},
  volume={28},
  pages={1055-1064}
}
Hallervorden–Spatz syndrome (HSS) is a devastating neurological disease, characterized by iron accumulation in the globus pallidus in the basal ganglia. Most HSS cases are caused by mutations in one of the four human pantothenate kinases (PANK2). This PANK2-caused subgroup of HSS is sometimes referred as PKAN (pantothenate-kinase-associated neurodegeneration). No effective treatment for PKAN or HSS is currently available. fumble, a Drosophila mutant that carries a mutation in Drosophila Pank… CONTINUE READING

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