Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats.

@article{Kawabata1999DietaryPO,
  title={Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats.},
  author={Kenji Kawabata and Takuji Tanaka and Tomoyuki Murakami and Tadashi A. Okada and Hiroaki Murai and Tomohiro Yamamoto and Akira Hara and Masahito Shimizu and Yoshihiro Yamada and Kengo Matsunaga and Toshiya Kuno and Naoki Yoshimi and Shigeyuki Sugie and Hideki Mori},
  journal={Carcinogenesis},
  year={1999},
  volume={20 11},
  pages={2109-15}
}
The modifying effect of dietary administration of defatted rice-germ and gamma-aminobutyric acid (GABA)-enriched defatted rice-germ on azoxymethane (AOM)-induced colon carcinogenesis was investigated in two experiments with male F344 rats. In the first experiment (the pilot study), the effects of the defatted rice-germ, the GABA-enriched defatted rice-germ and rice-germ on AOM-induced (15 mg/kg body wt once a week for 3 weeks) formation of aberrant crypt foci (ACF) were examined. The latter two… CONTINUE READING