Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation.

@article{Rocha2009DietaryPG,
  title={Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation.},
  author={Barbara Souza Rocha and Bruno Gago and Rui M. Barbosa and Jo{\~a}o Laranjinha},
  journal={Toxicology},
  year={2009},
  volume={265 1-2},
  pages={41-8}
}
Nitrite, considered a biological waste and toxic product, is being regarded as an important physiological molecule in nitric oxide (NO) biochemistry. Because the interaction of dietary phenolic compounds and nitrite would be kinetically (due to the high concentrations achieved) and thermodynamically (on basis of the redox potentials) feasible in the stomach, we have studied the potential reduction of nitrite by polyphenols present in several dietary sources. By measuring the time courses of *NO… CONTINUE READING