Dietary phosphorus acutely impairs endothelial function.

@article{Shuto2009DietaryPA,
  title={Dietary phosphorus acutely impairs endothelial function.},
  author={Emi Shuto and Yutaka Taketani and Rieko Tanaka and Nagakatsu Harada and Masashi Isshiki and Minako Sato and Kunitaka Nashiki and Kikuko Amo and Hironori Yamamoto and Yukihito Higashi and Yutaka Nakaya and Eiji Takeda},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 7},
  pages={
          1504-12
        }
}
Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acute effect of phosphorus loading on endothelial function in vitro and in vivo. Exposing bovine aortic endothelial cells to a phosphorus load increased production of reactive oxygen… Expand
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The results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. Expand
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Dietary phosphate restriction can improve aortic endothelial dysfunction in chronic kidney disease with hyperphosphatemia by increase in the activatory phosphorylations of endothelial nitric oxide synthase and Akt. Expand
Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway
  • K. Stevens, L. Denby, +6 authors A. Jardine
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2017
TLDR
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Habitual fluctuation of dietary P intake might be a cause of cardiovascular disease through endothelial dysfunction, especially in chronic kidney disease patients, and data indicate that repetitive fluctuations of plasma P caused by varying Dietary P intake can impair endothelial function via increased oxidative stress and inflammatory response. Expand
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TLDR
Evidence is found that inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus in healthy young men. Expand
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TLDR
Excess of calcium and phosphate in the circulation can promote the formation of protein-mineral complex called calciprotein particles (CPPs) in CKD, these CPPs contain less calcification inhibitors, induce inflammation, and promote VSMC calcification. Expand
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TLDR
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Serum phosphorus levels are associated with endothelial dysfunction in hypertensive patients.
TLDR
An impaired ACh-stimulated FBF is associated with serum phosphorus levels, within the normal range, in hypertensives, and the risk of endothelial dysfunction was about twice higher in patients in the second tertile and three-fold higher in the third. Expand
The Effect of Acute High Phosphate Intake on Muscle Metaboreflex Activation and Vascular Function.
TLDR
Although the muscle metaboreflex remains unaffected following acute high Pi consumption in young healthy men, endothelial function is impaired. Expand
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