Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs.

@article{NezSnchez2015DietaryPA,
  title={Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs.},
  author={Mar{\'i}a A N{\'u}{\~n}ez-S{\'a}nchez and Antonio Gonz{\'a}lez-Sarr{\'i}as and Mar{\'i}a Romo-Vaquero and Roc{\'i}o Garc{\'i}a-Villalba and Mar{\'i}a Victoria Selma and Francisco Tom{\'a}s Barber{\'a}n and Mar{\'i}a-Teresa Garc{\'i}a-Conesa and Juan Carlos Esp{\'i}n},
  journal={Molecular nutrition & food research},
  year={2015},
  volume={59 7},
  pages={1274-91}
}
Colorectal cancer (CRC) remains a major cause of cancer death worldwide. Over 70% of CRC cases are sporadic and related to lifestyle. Epidemiological studies inversely correlate CRC incidence with the intake of fruits and vegetables but not with their phenolic content. Preclinical studies using in vitro (cell lines) and animal models of CRC have reported anticancer effects for dietary phenolics through the regulation of different markers and signaling pathways. Herein, we review and contrast… CONTINUE READING
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