Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats.

@article{Pupovac2002DietaryPI,
  title={Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats.},
  author={Jelena Pupovac and G Harvey Anderson},
  journal={The Journal of nutrition},
  year={2002},
  volume={132 9},
  pages={2775-80}
}
We hypothesized that the digestion of proteins gives rise to peptides that initiate several satiety signals from the gut, and that the signals arising will be dependent on the protein source. The role of peripheral opioid and cholecystokinin (CCK)-A receptors was investigated. Casein, soy protein, and casein and soy hydrolysates were administered to rats by gavage (0.5 g protein/4 mL water). Food intake was measured over 2 h. The opioid receptor antagonist, naloxone methiodide (1.0 mg/kg) given… CONTINUE READING
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