Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-κB and Nrf2 in intestinal mucosa of mice.

@article{Varady2011DietaryOF,
  title={Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-κB and Nrf2 in intestinal mucosa of mice.},
  author={Juliane Varady and Klaus Eder and Robert Ringseis},
  journal={European journal of nutrition},
  year={2011},
  volume={50 8},
  pages={601-9}
}
PURPOSE Oxidized fats are known to induce oxidative stress resulting in the up-regulation of antioxidant enzymes, with the underlying mechanism being unclear. It is known, however, that the response of tissues to oxidative stress is mediated by redox-sensitive transcription factors such as NF-κB and Nrf2. The aim of this study, therefore, was to test the hypothesis that ingestion of an oxidized fat causes activation of these transcription factors in the small intestinal mucosa. METHODS Female… CONTINUE READING
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