Dietary obesity and neonatal sympathectomy. I. Effects on body composition and brown adipose.

@article{Levin1984DietaryOA,
  title={Dietary obesity and neonatal sympathectomy. I. Effects on body composition and brown adipose.},
  author={Barry E. Levin and Joseph M Triscari and Eugene Marquet and A. Charlene Sullivan},
  journal={The American journal of physiology},
  year={1984},
  volume={247 6 Pt 2},
  pages={R979-87}
}
The effect of neonatal sympathectomy with guanethidine (50 mg/kg for 3 wk) on the development of diet-induced obesity (DIO) was assessed by raising guanethidine-(G) or saline-treated (S) Sprague-Dawley rats in small litters (4-5 pups/dam) and feeding a high-calorie diet from weaning (n = 29-30) or by raising similarly treated rats in normal litters (10 pups/dam) and feeding chow from weaning (n = 29-30). Sympathectomy depleted norepinephrine (NE) levels 65-98% in all organs except the adrenals… CONTINUE READING