Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.

@article{Stokes2009DietaryNP,
  title={Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.},
  author={Karen Y. Stokes and Tammy Renee Dugas and Yaoping Tang and Harsha K Garg and Eric Guidry and Nathan S. Bryan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 5},
  pages={H1281-8}
}
The nitrite anion is an endogenous product of mammalian nitric oxide (NO) metabolism, a key intermediate in the nitrogen cycle in plants, and a constituent of many foods. Research over the past 6 years has revealed surprising biological and cytoprotective activity of this anion. Hypercholesterolemia causes a proinflammatory phenotype in the microcirculation. This phenotype appears to result from a decline in NO bioavailability that results from a reduction in NO biosynthesis, inactivation of NO… CONTINUE READING
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