Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

  title={Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.},
  author={Stephen J Bailey and Paul G. Winyard and Anni Vanhatalo and Jamie R. Blackwell and Fred J. DiMenna and Daryl P. Wilkerson and Joanna M. Tarr and Nigel Benjamin and Andrew M. Jones},
  journal={Journal of applied physiology},
  volume={107 4},
Pharmacological sodium nitrate supplementation has been reported to reduce the O2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic nitrate in the form of beetroot juice (BR) would reduce the O2 cost of submaximal exercise and enhance the tolerance to high-intensity exercise. In a double-blind, placebo (PL)-controlled, crossover study, eight men (aged 19-38 yr) consumed 500 ml/day of either BR (containing 11.2 +/- 0.6 mM of nitrate… 

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Acute dietary nitrate supplementation improves cycling time trial performance.

It is suggested that acute dietary nitrate supplementation with 0.5 L of BR improves cycling economy, as demonstrated by a higher PO for the same VO2 and enhances both 4- and 16.1-km cycling TT performance.

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.

Similar to the effects of increased dietary NO(3)(-) intake, elevating NO bioavailability through dietary L-Arg supplementation reduced the O(2) cost of moderate-intensity exercise and blunted the VO(2), slow component and extended the time to exhaustion during severe- intensity exercise.

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

The reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production.

Dietary nitrate and O₂ consumption during exercise.

Reducing the O(2) cost for a given sub-maximal work rate following nitrate ingestion indicates that muscle efficiency is enhanced either as a consequence of a reduced energy cost of contraction or enhanced mitochondrial efficiency.

Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise.

It is indicated that dietary NO(3)(-) supplementation acutely reduces BP and the O(2) cost of submaximal exercise and that these effects are maintained for at least 15 days if supplementation is continued.

Aerobic Fitness Affects the Exercise Performance Responses to Nitrate Supplementation.

It is suggested that the individual aerobic fitness level affects the ergogenic benefits induced by dietary nitrate supplementation and the optimal nitrate loading regimen required to elevate plasma [NO2] and to enhance performance in elite athletes is different from that of low-fit subjects and requires further studies.

Influence of dietary nitrate on the physiological determinants of exercise performance: a critical review.

  • A. Jones
  • Education
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2014
A "state-of-the-art" review of the literature pertinent to the evaluation of the efficacy of nitrate supplementation in altering the physiological determinants of sport and exercise performance is provided.



Effects of Prior Exercise on Metabolic and Gas Exchange Responses to Exercise

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Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise.

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Nitric oxide synthase inhibition speeds oxygen uptake kinetics in horses during moderate domain running

Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans.

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Influence of nitric oxide synthase inhibition on pulmonary O2 uptake kinetics during supra‐maximal exercise in humans

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Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

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