Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

  title={Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.},
  author={Stephen J Bailey and Jonathan Fulford and Anni Vanhatalo and Paul G. Winyard and Jamie R. Blackwell and Fred J. DiMenna and Daryl P. Wilkerson and Nigel Benjamin and Andrew M. Jones},
  journal={Journal of applied physiology},
  volume={109 1},
The purpose of this study was to elucidate the mechanistic bases for the reported reduction in the O(2) cost of exercise following short-term dietary nitrate (NO(3)(-)) supplementation. In a randomized, double-blind, crossover study, seven men (aged 19-38 yr) consumed 500 ml/day of either nitrate-rich beet root juice (BR, 5.1 mmol of NO(3)(-)/day) or placebo (PL, with negligible nitrate content) for 6 consecutive days, and completed a series of low-intensity and high-intensity "step" exercise… 

Figures and Tables from this paper

The effect of nitrate supplementation on muscle contraction in healthy adults

It is suggested that four days of supplementation elicits peripheral responses in muscle that attenuate muscular fatigue during exhaustive exercise under hypovolemic conditions.

The Effects of Nitrate-Rich Supplementation on Neuromuscular Efficiency during Heavy Resistance Exercise

Objective: Nitrate-rich (NR) supplements can enhance exercise performance by improving neuromuscular function and the aerobic cost of exercise. However, little is known about the effects of nitrate

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.

Similar to the effects of increased dietary NO(3)(-) intake, elevating NO bioavailability through dietary L-Arg supplementation reduced the O(2) cost of moderate-intensity exercise and blunted the VO(2), slow component and extended the time to exhaustion during severe- intensity exercise.

Acute dietary nitrate supplementation improves cycling time trial performance.

It is suggested that acute dietary nitrate supplementation with 0.5 L of BR improves cycling economy, as demonstrated by a higher PO for the same VO2 and enhances both 4- and 16.1-km cycling TT performance.

Dietary nitrate and O₂ consumption during exercise.

Reducing the O(2) cost for a given sub-maximal work rate following nitrate ingestion indicates that muscle efficiency is enhanced either as a consequence of a reduced energy cost of contraction or enhanced mitochondrial efficiency.

Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women.

Acute dietary nitrate supplementation does not attenuate oxidative stress or the hemodynamic response during submaximal exercise in hypobaric hypoxia.

It is concluded that an acute, pre-exercise dose of dietary nitrate yielded no beneficial changes in oxidative stress, SaO2, BP, or HR in healthy, aerobically fit men exercising at 3500 m.

Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults.

Dietary nitrate supplementation reduced resting blood pressure and improved Vo(2) kinetics during treadmill walking in healthy older adults but did not improve walking or cognitive performance, which may have implications for the enhancement of cardiovascular health in older age.

Dietary Nitrate Supplementation Improves Exercise Tolerance by Reducing Muscle Fatigue and Perceptual Responses

Dietary nitrate supplementation attenuated the development of muscle fatigue by reducing the exercise-induced impairments in contractile muscle function; and lowered the perception of both effort and leg muscle pain during exercise.



Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.

Influence of endurance training on muscle [PCr] kinetics during high-intensity exercise.

The attenuation of the [PCr] slow component might be mechanistically linked with enhanced exercise tolerance following endurance training.

Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans.

Six sessions of RST, but not ET, resulted in changes in [HHb] kinetics consistent with enhanced fractional muscle O(2) extraction, faster Vo( 2) kinetics, and an increased tolerance to high-intensity exercise.

Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise.

The speeding of the primary component Vo(2) kinetics after L-NAME infusion indicates that at least part of the intrinsic inertia to oxidative metabolism at the onset of heavy-intensity exercise may result from inhibition of mitochondrial Vo( 2) by nitric oxide.

ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise.

The present data suggest that the rate of ATP turnover increases during intense exercise at a constant work rate, and mechanical efficiency declines as intense exercise is continued.

Muscular and pulmonary O2 uptake kinetics during moderate‐ and high‐intensity sub‐maximal knee‐extensor exercise in humans

The phase II kinetics reflect kinetics during exercise but not during recovery where caution in data interpretation is advised, indicating that increased probably makes a small contribution to during the first 15–20 s of exercise.

Live high:train low increases muscle buffer capacity and submaximal cycling efficiency.

Reduced VO2 during normoxic exercise after LHTL suggests that improved exercise efficiency is a fundamental adaptation to L HTL, and is the first study to show that hypoxic exposure, per se, increases muscle buffer capacity.

Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high‐intensity knee‐extension exercise in humans

It is demonstrated that the V̇O2 responses relative to the work rate input for high‐intensity exercise are non‐linear, as are, it appears, the putative phosphate‐linked controllers for which [PCr] serves as a surrogate.