Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.

  title={Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.},
  author={Aarti A Kenjale and Katherine L. Ham and Thomas Stabler and Jennifer L. Robbins and Johanna L Johnson and Mitch Vanbruggen and Grayson Privette and Eunji Yim and William E Kraus and Jason D. Allen},
  journal={Journal of applied physiology},
  volume={110 6},
Peripheral arterial disease (PAD) results in a failure to adequately supply blood and oxygen (O(2)) to working tissues and presents as claudication pain during walking. Nitric oxide (NO) bioavailability is essential for vascular health and function. Plasma nitrite (NO(2)(-)) is a marker of vascular NO production but may also be a protected circulating "source" that can be converted to NO during hypoxic conditions, possibly aiding perfusion. We hypothesized that dietary supplementation of… CONTINUE READING
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