Dietary niacin deficiency lowers tissue poly(ADP-ribose) and NAD+ concentrations in Fischer-344 rats.

@article{Rawling1994DietaryND,
  title={Dietary niacin deficiency lowers tissue poly(ADP-ribose) and NAD+ concentrations in Fischer-344 rats.},
  author={Jean M. Rawling and Tanya Jackson and Eric R. Driscoll and James B. Kirkland},
  journal={The Journal of nutrition},
  year={1994},
  volume={124 9},
  pages={1597-603}
}
Poly(ADP-ribose) is synthesized in response to DNA strand breaks, using NAD+ as substrate, and has been implicated in the process of DNA repair. Because NAD+ can be synthesized from niacin or tryptophan, both of these components must be manipulated to alter niacin status. Six dietary treatments were used, including niacin-deficient (ND) diets and niacin-replete (NR) diets consumed ad libitum and the NR diets pair-fed (PF) to the ND intake. The ND, NR and PF diets contained either 80 g casein… CONTINUE READING
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