Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain.

@article{Igarashi2012DietaryNP,
  title={Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain.},
  author={Miki Igarashi and Hyungwook Kim and Lisa Chang and Kaizong Ma and Stanley I. Rapoport},
  journal={Journal of neurochemistry},
  year={2012},
  volume={120 6},
  pages={985-97}
}
Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selective calcium-independent phospholipase A(2) (iPLA(2) )-VIA expression. We hypothesized that these changes are accompanied by up-regulated brain DHA metabolic rates. Using a fatty acid… CONTINUE READING
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This article is a US Government work and is in the public domain in the USA J

  • Published
  • Neurochem. (2012) 120, 985–997
  • 2011
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