Dietary n-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects.

@article{Serini2011DietaryNP,
  title={Dietary n-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects.},
  author={Simona Serini and Elena Fasano and Elisabetta Piccioni and Achille Cittadini and Gabriella Calviello},
  journal={Chemical research in toxicology},
  year={2011},
  volume={24 12},
  pages={
          2093-105
        }
}
There is some evidence to support the toxicity of polyunsaturated fatty acids (PUFAs) and their oxidative products, suggesting their involvement in the pathogenesis of different chronic diseases, including cancer. It has been shown that products of PUFA oxidation may exert a carcinogenic action by forming mutagenic adducts with DNA. However, a large amount of evidence accumulated over several decades has indicated the beneficial effects of administration of n-3 PUFAs in the prevention and… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence

  • BioMed research international
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 177 REFERENCES

A fi sh - oil - rich diet reduces vascular oxidative stress in apoE (  /  ) mice

N. Zarkovic, K. Zarkovic, +3 authors M. T. andMitjavila
  • Cancer Prev . Res . ( Phila )
  • 2010

Antineoplastic e ff ects of n - 3 polyunsaturated fatty acids in combination with drugs and radiotherapy : preventive and therapeutic strategies

S. Serini, V. Donato, +10 authors G. Calviello
  • Nutr . Cancer
  • 2010

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010