Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats.

@article{Branda2002DietaryMO,
  title={Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats.},
  author={Richard F. Branda and Elice M Brooks and Zhuan Chen and Shelly J Naud and Janice A. Nicklas},
  journal={Mutation research},
  year={2002},
  volume={501 1-2},
  pages={29-36}
}
Mitochondrial DNA (mtDNA) is particularly susceptible to mutation by alkylating agents, and mitochondrial damage may contribute to the efficacy and toxicity of these agents. We found that folate supplementation decreased the frequency of the "common deletion" (4.8kb, bases 8103-12,936) in liver from untreated rats and from animals treated with cyclophosphamide but not 5-fluorouracil (5-FU). The relative abundance of mitochondrial DNA was greater after chemotherapy but there was no effect of… CONTINUE READING