Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice.

@article{Fernandes1995DietaryLA,
  title={Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice.},
  author={Gabriel Henrique Barroso Viana Fernandes and Bysani Chandrasekar and Dean A. Troyer and Jaya T. Venkatraman and R A Good},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 14},
  pages={6494-8}
}
We have studied the effects of food restriction (FR) and substitution of fish oil (FO; omega 3) for corn oil (CO; omega 6) on breast tumor incidence and survival in mouse mammary tumor virus/v-Ha-ras transgenic (Onco) mice. The diets were as follows: group 1, 5% (wt/wt) CO fed ad libitum (AL); group 2, 5% CO, restricted calories (40% fewer calories than AL; FR); group 3, 20% CO fed AL; and group 4, 20% FO fed AL. After 3 years, 40% of FR Onco (group 2) mice were alive, whereas there were no… CONTINUE READING

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