Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.

  title={Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.},
  author={Susan E. McCann and Paola Muti and D. Fransaer Vito and Stephen B. Edge and Maurizio Trevisan and Jo L Freudenheim},
  journal={International journal of cancer},
  volume={111 3},
Lignans are plant compounds metabolized in the mammalian gut to produce the phytoestrogens enterolactone and enterodiol. Because estrogens have been linked to breast cancer etiology, lignans could affect breast cancer risk through modulation of endogenous estrogen metabolism or competitive inhibition with estrogen receptors. We examined breast cancer risk and dietary lignan intake in a population-based case-control study of 1,122 women with primary, incident, histologically confirmed breast… CONTINUE READING
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