Dietary isothiocyanates as confounding factors in the molecular epidemiology of colon cancer.

  • Brian Ketterer
  • Published 1998 in
    Cancer epidemiology, biomarkers & prevention : a…
In this issue, Lin et a!. ( 1) show convincing statistics that subjects exposed to dietary broccoli who have a GSTM 12 null phenotype are less susceptible to colon cancer than those who are GSTMI positive. The expected effect of a GSTM1 null phenotype is greater, not less, susceptibility to cancers due to reduced carcinogen detoxification by GSTM1 (2, 3… CONTINUE READING