Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.

@article{Cooksey2010DietaryIR,
  title={Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.},
  author={Robert C. Cooksey and Deborah T Jones and Scott Gabrielsen and Jingyu Huang and Judith A. Simcox and Bai Luo and Yudi A Soesanto and Hugh Young Rienhoff and E. Dale Abel and Donald A. McClain},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 6},
  pages={E1236-43}
}
Iron overload can cause insulin deficiency, but in some cases this may be insufficient to result in diabetes. We hypothesized that the protective effects of decreased iron would be more significant with increased beta-cell demand and stress. Therefore, we treated the ob/ob mouse model of type 2 diabetes with an iron-restricted diet (35 mg/kg iron) or with an oral iron chelator. Control mice were fed normal chow containing 500 mg/kg iron. Neither treatment resulted in iron deficiency or anemia… CONTINUE READING
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