Dietary intervention increases n‐3 long‐chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity

@article{Haugaard2006DietaryII,
  title={Dietary intervention increases n‐3 long‐chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity},
  author={Steen Bendix Haugaard and Sten Madsbad and C. -E. H{\o}y and Allan A. Vaag},
  journal={Clinical Endocrinology},
  year={2006},
  volume={64}
}
Objective  Cross‐sectional studies suggest that the fatty acid (FA) composition of phospholipids in skeletal muscle cell membrane may modulate insulin sensitivity in humans. We examined the impact of a hypocaloric low‐fat dietary intervention on membrane FA composition and insulin sensitivity. 
Desaturation of Skeletal Muscle Structural and Depot Lipids in Obese Individuals during a Very‐Low‐Calorie Diet Intervention
Objective: This study investigated whether a very‐lowcalorie dietary intervention (VLCD) may influence composition of skeletal muscle cell membrane phospholipid and composition and concentration of
Sex and muscle structural lipids in obese subjects – an impact on insulin action?
TLDR
The increased extramyocellular fat mass of obese women may act in a paracrine manner such that its release of free FA and cytokines may hamper in situ desaturation and elongation of FA in skeletal muscle phospholipids.
Plasma long‐chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one‐year nutritional intervention
Aim:  To assess the association between changes in plasma long‐chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1‐year nutritional intervention in normolipidaemic
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
TLDR
LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte membrane or adiponectin.
The effect of dietary fat content on phospholipid fatty acid profile is muscle fiber type dependent.
TLDR
The pattern of FA uptake, expression, and diet-induced changes in FA desaturating and elongating enzymes maintained higher FA unsaturation in EDL muscles, and the fiber type composition of skeletal muscles and their distribution may be important in the development and progression of obesity and IR.
Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans
TLDR
Dietary EPA+DHA does not improve peripheral glucose disposal, insulin secretion, or skeletal muscle mitochondrial function in insulin-resistant nondiabetic humans and is not associated with any improvements in clinically meaningful outcomes.
Incorporation of Omega-3 Fatty Acids Into Human Skeletal Muscle Sarcolemmal and Mitochondrial Membranes Following 12 Weeks of Fish Oil Supplementation
TLDR
Data revealed that mitochondrial and sarcolemmal membranes display unique phospholipid compositions and responses to FO supplementation, and the content of omega-3 FAs, EPA and DHA, were increased in whole muscle, and mitochondrial membranes, and as a result the omega-6/omega-3 ratios were dramatically decreased while the unsaturation indexes were increased.
N-3 POLYUNSATURATED ACIDS IN ERYTHROCYTE PHOSPHOLIPIDS ARE ASSOCIATED WITH INSULIN SENSITIVITY IN OBESE PATIENTS ON A TYPICAL SERBIAN DIET
TLDR
The data indicate that the percentage of n-3 PUFAs in erythrocyte phospholipids is linked with insulin sensitivity parameters in obese patients.
Prevention of insulin resistance by n-3 polyunsaturated fatty acids
  • D. Fedor, D. Kelley
  • Medicine
    Current opinion in clinical nutrition and metabolic care
  • 2009
TLDR
Increased intake of n-3 PUFA should be part of an overall healthy lifestyle that includes weight control, exercise, and reduction in the intake of refined sugars, n-6, saturated, and trans fatty acids.
Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial.
TLDR
Six months of high-dose ω-3 supplementation raised plasma and adiposeπ-3 fatty acid concentrations but had no beneficial effects on adipose tissue lipolysis or inflammation in insulin-resistant adults.
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