Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.

  title={Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.},
  author={Craig Lawrence Kien and Janice Yanushka Bunn and Robert F. Stevens and James Bain and Olga Ikayeva and Karen I. Crain and Timothy R. Koves and Deborah M. Muoio},
  journal={The American journal of clinical nutrition},
  volume={99 3},
BACKGROUND Epidemiologic evidence has suggested that diets with a high ratio of palmitic acid (PA) to oleic acid (OA) increase risk of cardiovascular disease (CVD). OBJECTIVE To gain additional insights into the relative effect of dietary fatty acids and their metabolism on CVD risk, we sought to identify a metabolomic signature that tracks with diet-induced changes in blood lipid concentrations and whole-body fat oxidation. DESIGN We applied comprehensive metabolomic profiling tools to… CONTINUE READING
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