Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.

@article{Geleijnse2004DietaryIO,
  title={Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.},
  author={Johanna Marianna Geleijnse and Cees Vermeer and Diederick E. Grobbee and Leon J. Schurgers and Marjo H. J. Knapen and Irene M. van der Meer and Albert Hofman and Jacqueline C. M. Witteman},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 11},
  pages={
          3100-5
        }
}
Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. [...] Key Method The analysis included 4807 subjects with dietary data and no history of myocardial infarction at baseline (1990-1993) who were followed until January 1, 2000. The risk of incident CHD, all-cause mortality, and aortic atherosclerosis was studied in tertiles of energy-adjusted vitamin K intake after adjustment for age, gender, BMI, smoking, diabetes, education, and dietary factors. The…Expand
High dietary menaquinone intake is associated with reduced coronary calcification.
TLDR
It is shown that high dietary menaquinone intake, but probably not phylloquinone, is associated with reduced coronary calcification and could therefore be important to prevent cardiovascular disease.
A high menaquinone intake reduces the incidence of coronary heart disease.
TLDR
A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD, however, more research is necessary to define optimal intake levels of vitamin K intake for the prevention of CHD.
Phylloquinone intake and risk of cardiovascular diseases in men.
TLDR
High phylloquinone intake may be a marker of dietary patterns associated with lower CHD risk and useful when used within that context, according to the results of a large population based study conducted in 40,087 men during 1986-2000.
Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
TLDR
Neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk in a prospective cohort of 35 476 healthy subjects.
The relationship between vitamin K and peripheral arterial disease.
TLDR
High intake of menaquinones was associated with a reduced risk of PAD, at least in hypertensive participants, and high intake of phylloquinone was not associated with PAD.
Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
TLDR
Vitamin K insufficiency, as assessed by high plasma dp-ucMGP concentrations is associated with an increased risk for cardiovascular disease independent of classical risk factors and vitamin D status.
Phylloquinone and Vitamin D Status: Associations with Incident Chronic Kidney Disease in the Framingham Offspring Cohort
TLDR
Higher plasma phylloquinone levels are associated with an increased risk of incident CKD and albuminuria, contradicting the hypothesis that deficiencies of vitamins D and K may be associated with incidents of chronic kidney disease among members of the general population.
Vitamin K2 (menaquinone) Supplementation and its Benefits in Cardiovascular Disease, Osteoporosis, and Cancer
TLDR
The authors conclude that menaquinone supplementation has been shown to improve carboxylation of osteocalcin and matrix-Gla protein to their active forms, two proteins that possess important roles in calcium distribution.
Response to “Effects of Vitamin K intake on gamma-carboxylated proteins, bone fractures, and vascular calcifications”
TLDR
It is not clear whether vitamin K intake has beneficial effects on vascular health, in addition to bone health, so the effects of vitamin K on vascular calcification with a careful consideration of the interaction between vitamin K and intake of calcium and vitamin D is investigated.
Vitamin K supplementation and progression of coronary artery calcium in older men and women.
TLDR
Phylloquinone supplementation slows the progression of CAC in healthy older adults with preexisting CAC, independent of its effect on total MGP concentrations.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Nutritional Intake of Vitamins K1 (Phylloquinone) and K2 (Menaquinone) in The Netherlands
Vitamin K plays a key role in the hepatic synthesis of blood clotting factors. Recently, other tissues (bone, vessel wall) were shown to produce vitamin K-dependent proteins not involved in blood
Development of a diet low in vitamin K-1 (phylloquinone).
TLDR
The diet proved useful in altering apparent nutritional status for vitamin K-1; after ingestion of the diet for 6 days, plasma concentrations of vitaminK-1 decreased by 80% and fell below the established normal range.
Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats
TLDR
The observed differences between K1 and MK-4 with respect to inhibition of arterial calcification may be explained by both differences in their tissue bioavailability and cofactor utilization in the reductase/carboxylase reaction.
Differential lipoprotein transport pathways of K-vitamins in healthy subjects.
TLDR
The relatively large impact of menaquinones on extra-hepatic vitamin K status than generally assumed is suggested and the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4.
Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations.
TLDR
It is concluded that the contribution of K(2) vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.
Role of K vitamins in the regulation of tissue calcification
TLDR
The only known function of vitamin K in mammals is that it serves as a cofactor for the endoplasmic enzyme gamma-glutamyl carboxylase, where it promotes the post-translational conversion of selective protein-bound glutamate residues into gamma-carboxy glutamate (Gla).
Vitamin K1 (Phylloquinone) content of foods: a provisional table
Abstract A provisional table on the vitamin K 1 (phylloquinone) content of foods was compiled in response to the expressed need for tabulated data by the public and professionals in medicine,
Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study.
OBJECTIVE To identify important food sources and estimate dietary intake of vitamin K-1 (phylloquinone) in the American diet. DESIGN Core foods from the US Food and Drug Administration (FDA) Total
Vitamin K and human nutrition.
  • J. Suttie
  • Chemistry, Medicine
    Journal of the American Dietetic Association
  • 1992
TLDR
A Recommended Dietary Allowance of 1 micrograms/kg body weight has been established for vitamin K and advances in analytic techniques and more sensitive clotting factor assays will make it possible to define the human requirement for this vitamin more accurately.
Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats.
TLDR
It is concluded that the colonic absorption of all three forms of vitamin K is extremely poor, suggesting that physiological menaquinones in the colon do not contribute substantially to vitamin K status in rats.
...
1
2
3
4
...