Dietary-induced ERbeta upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice.

@article{Barone2010DietaryinducedEU,
  title={Dietary-induced ERbeta upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice.},
  author={Michele Barone and Sabina Tanzi and Katia Lofano and Maria Principia Scavo and Maria Pricci and Lucia Demarinis and Samanta Papagni and Raffaella Guido and Eugenio Maiorano and Giuseppe Ingravallo and Maria Cristina Comelli and Antonio Francavilla and Alfredo Di Leo},
  journal={Carcinogenesis},
  year={2010},
  volume={31 2},
  pages={269-74}
}
Most sporadic colorectal cancers (CRCs) develop through the adenoma-carcinoma sequence pathway and are initiated by adenomatous polyposis coli (APC) gene mutations. Estrogen receptor beta (ERbeta) is recognized to progressively reduce its expression in adenomatous and carcinomatous tissues in humans. Moreover, ERbeta deficiency enhances small intestinal tumorigenesis in rodents. In the Apc(Min/+) mouse model, we evaluated intestinal polyp development and ERbeta expression plus other biological… CONTINUE READING

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