Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates.

@article{Thorgeirsson1996DietaryHA,
  title={Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates.},
  author={Unnur P. Thorgeirsson and Elizabeth G. Snyderwine and Daniel Eduardo G{\'o}mez and Richard H. Adamson},
  journal={In vivo},
  year={1996},
  volume={10 2},
  pages={145-52}
}
During the cooking of meats, several highly potent mutagenic heterocyclic amines (HCAs) are produced. To date, 10 HCAs have been shown to be carcinogenic in rodents, and one HCA, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), has been shown to be a potent hepatocarcinogen in nonhuman primates. In this report, we discuss the role of metabolic activation and DNA adduct formation in the carcinogenicity of HCAs, especially in nonhuman primates. The potent hepatocarcinogenicity of IQ in cynomolgus… CONTINUE READING