Dietary heme induces acute oxidative stress, but delayed cytotoxicity and compensatory hyperproliferation in mouse colon.

@article{Ijssennagger2013DietaryHI,
  title={Dietary heme induces acute oxidative stress, but delayed cytotoxicity and compensatory hyperproliferation in mouse colon.},
  author={Noortje Ijssennagger and Anneke Rijnierse and Nicole J. W. de Wit and Mark V. Boekschoten and Jan Dekker and Arjan Schonewille and Michael M{\"u}ller and Roelof van der Meer},
  journal={Carcinogenesis},
  year={2013},
  volume={34 7},
  pages={1628-35}
}
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by generating cytotoxic and oxidative stress. Recently, we found that this surface injury is compensated by hyperproliferation and hyperplasia of crypt cells, which was induced by a changed surface to crypt signaling. It is unknown whether this changed signaling is caused by cytotoxic stress and/or oxidative stress, as these processes were never studied… CONTINUE READING
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