Dietary folates and cancer risk in a network of case-control studies.

  title={Dietary folates and cancer risk in a network of case-control studies.},
  author={Alessandra Tavani and Stefano Malerba and Claudio Pelucchi and Luigino Dal Maso and Antonella Zucchetto and Diego Serraino and Fabio Levi and Maurizio Montella and Silvia Franceschi and Antonella Zambon and Carlo La La Vecchia},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={23 10},
BACKGROUND Folate deficiency leads to DNA damage and inadequate repair, caused by a decreased synthesis of thymidylate and purines. We analyzed the relationship between dietary folate intake and the risk of several cancers. PATIENTS AND METHODS The study is based on a network of case-control studies conducted in Italy and Switzerland in 1991-2009. The odds ratios (ORs) for dietary folate intake were estimated by multiple logistic regression models, adjusted for major identified confounding… CONTINUE READING
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