Dietary flavonol quercetin induces chloride secretion in rat colon.

  title={Dietary flavonol quercetin induces chloride secretion in rat colon.},
  author={Rainer Cermak and Ursula F{\"o}llmer and Siegfried Wolffram},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={275 5},
The aim of this study was to investigate the possible effects of the flavonol quercetin, the most abundant dietary flavonoid, on the intestinal mucosa. In vitro experiments were performed with various segments of the rat intestine, using the Ussing chamber technique. Quercetin increased the short-circuit current ( I sc) in the jejunum, ileum, and proximal and distal colon. Additional experiments were performed using preparations of the proximal colon. The maximum effective dose of quercetin was… 
The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium
It is concluded that at least part of the quercetin‐induced Cl− secretion can be explained by an activation of basolateral K+ channels.
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes
Genistein is able to activate luminal CFTR Cl− conductance in non‐CF tissues and mutant CFTR in oocytes, however, additional inhibitory effects on basolateral K+ conductance and missing effects in native CF tissues do not support the use for pharmacological intervention in CF.