Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.

@article{Salmela2009DietaryFF,
  title={Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.},
  author={A Salmela and Jeroen Pouwels and Asta Varis and Anu M. Kukkonen and Pauliina Toivonen and Pasi K Halonen and Merja Per{\"a}l{\"a} and Olli Kallioniemi and Gary J Gorbsky and Marko Johannes Kallio},
  journal={Carcinogenesis},
  year={2009},
  volume={30 6},
  pages={1032-40}
}
Fisetin is a natural flavonol present in edible vegetables, fruits and wine at 2-160 microg/g concentrations and an ingredient in nutritional supplements with much higher concentrations. The compound has been reported to exert anticarcinogenic effects as well as antioxidant and anti-inflammatory activity via its ability to act as an inhibitor of cell proliferation and free radical scavenger, respectively. Our cell-based high-throughput screen for small molecules that override chemically induced… CONTINUE READING