Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects.

@article{Kremer1990DietaryFO,
  title={Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects.},
  author={Joel M. Kremer and David A Lawrence and William Jubiz and R DiGiacomo and Richard I. Rynes and Leland Earl Bartholomew and Michael P Sherman},
  journal={Arthritis and rheumatism},
  year={1990},
  volume={33 6},
  pages={
          810-20
        }
}
Forty-nine patients with active rheumatoid arthritis completed a 24-week, prospective, double-blind, randomized study of dietary supplementation with 2 different dosages of fish oil and 1 dosage of olive oil. Clinical evaluations were performed at baseline and every 6 weeks thereafter, and immunologic variables were measured at baseline and after 24 weeks of study. The 3 groups of patients were matched for age, sex, disease severity, and use of disease-modifying antirheumatic drugs (DMARDs… Expand
Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
TLDR
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TLDR
Patients taking dietary supplements of fish oil exhibit improvements in clinical parameters of disease activity from baseline, including the number of tender joints, and these improvements are associated with significant decreases in levels of IL-1 beta from baseline. Expand
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TLDR
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TLDR
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A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis.
TLDR
Results suggested that in dogs with chronic osteoarthritis receiving carProfen because of signs of pain, feeding a diet supplemented with fish oil omega-3 fatty acids may allow for a reduction in carprofen dosage. Expand
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TLDR
FO was associated with benefits additional to those achieved by combination ‘treat-to-target’ DMARDs with similar MTX use, which included reduced triple DMARD failure and a higher rate of ACR remission. Expand
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TLDR
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Combined Add-on Supplementation of Omega-3 Fatty Acids, Vitamin E, Vitamin A, Copper, and Selenium in Rheumatoid Arthritis
TLDR
A twelve week add-on supplementation of a combined food supplement (ω-3 FA + antioxidants) effected modest but not significant changes in the clinical parameters in RA. Expand
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TLDR
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References

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Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled, crossover study.
STUDY OBJECTIVE to determine the efficacy of fish-oil dietary supplements in active rheumatoid arthritis and their effect on neutrophil leukotriene levels. DESIGN nonrandomized, double-blinded,Expand
EFFECTS OF MANIPULATION OF DIETARY FATTY ACIDS ON CLINICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS
TLDR
On follow-up evaluation 1-2 months after stopping the diet, the experimental group had deteriorated significantly in patient and physician global evaluation of disease activity, pain assessment, and number of tender joints. Expand
Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis.
TLDR
Dietary supplementation with fish oil was compared with an olive oil supplement over a 12-week period in patients with rheumatoid arthritis receiving established conventional therapies, with an improvement in tender joint score and grip strength seen at 12 weeks but not in the olive oil treated group. Expand
Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis.
TLDR
Patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of Max-EPA fish oil, daily, for 6 weeks with modulation of measures of leukocyte inflammatory potential, suggesting that fish oil supplementation may have an antiinflammatory effect. Expand
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TLDR
The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study. Expand
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.
TLDR
It is concluded that the synthesis ofIL-1 beta, IL-1 alpha, and tumor necrosis factor can be suppressed by dietary supplementation with long-chain n-3 fatty acids. Expand
Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation.
TLDR
The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving the fish oil/EPO mixture, suggesting that EPO may be of benefit in alleviating the murine form of the disease. Expand
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function
Abstract The effects of dietary fish-oil fatty acids on the function of the 5-lipoxygenase pathway of peripheral-blood polymorphonuclear leukocytes and monocytes were determined in seven normalExpand
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function.
TLDR
It is concluded that diets enriched with fish-oil-derived fatty acids may have antiinflammatory effects by inhibiting the 5-lipoxygenase pathway in neutrophils and monocytes and inhibition of the leukotriene B4-mediated functions of neutrophil. Expand
Essential fatty acids and immune response
  • D. Hwang
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
TLDR
Growing evidence now suggests that the PGE group of prostaglandins can serve as a negative feedback modulator of immune response, and in vitro effects of other cyclooxygenase‐derived products, such as PGI2 and thromboxane A2 (TXA2), have not been well established, perhaps because of their instability in aqueous media. Expand
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