Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue

Abstract

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies intracellular glucocorticoid action by converting inactive glucocorticoids to their active forms in vivo. Adipose-specific overexpression of 11β-HSD1 induces metabolic syndrome in mice, whereas 11β-HSD1 null mice are resistant to it. Dietary trans and saturated fatty acids (TFAs and… (More)
DOI: 10.1186/1476-511X-9-111

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@inproceedings{Prasad2010DietaryFA, title={Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue}, author={Sakamuri SS Vara Prasad and Shanmugam S Jeya Kumar and Putcha Uday Kumar and Syed S Y H Qadri and Ayyalasomayajula Vajreswari}, booktitle={Lipids in Health and Disease}, year={2010} }