Dietary fat-induced taurocholic acid production promotes pathobiont and colitis in IL-10−/− mice

@inproceedings{Devkota2012DietaryFT,
  title={Dietary fat-induced taurocholic acid production promotes pathobiont and colitis in IL-10−/− mice},
  author={Suzanne Devkota and Yunwei Wang and Mark W Musch and Vanessa Leone and Hannah Fehlner-Peach and Anuradha Nadimpalli and Dionysios A. Antonopoulos and Bana Jabri and Eugene B Chang},
  booktitle={Nature},
  year={2012}
}
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Here we show that consumption of a diet high in saturated (milk-derived) fat, but not polyunsaturated (safflower oil) fat, changes the conditions for microbial assemblage and promotes the expansion of a low-abundance, sulphite-reducing pathobiont, Bilophila wadsworthia. This was associated with a pro… CONTINUE READING
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