Dietary fat effects on the initiation and promotion of two-stage skin tumorigenesis in the SENCAR mouse.

@article{Birt1989DietaryFE,
  title={Dietary fat effects on the initiation and promotion of two-stage skin tumorigenesis in the SENCAR mouse.},
  author={Diane F. Birt and Lawrence T. White and Bongkun Choi and Jifi C. Pelling},
  journal={Cancer research},
  year={1989},
  volume={49 15},
  pages={4170-4}
}
We investigated the influence of dietary corn oil on initiation of skin tumors in SENCAR mice with 7,12-dimethylbenz(a)anthracene (DMBA) (10 nmol at 8 to 9 wk of age) and the promotion of these tumors with 12-O-tetradecanoylphorbol-13-acetate (TPA) (3.2 nmol twice weekly for 20 wk). Diet high in corn oil (24.6%) was fed, in comparison with control diet (5%), to mice during two time schedules: (a) high-fat diet was fed preceding and for 1 wk following DMBA to assess the effects of high corn oil… CONTINUE READING

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