Dietary fat and breast cancer mortality: A systematic review and meta-analysis

  title={Dietary fat and breast cancer mortality: A systematic review and meta-analysis},
  author={Sarah F. Brennan and Jayne V. Woodside and Paula M Lunny and Chris R. Cardwell and Marie M. Cantwell},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={1999 - 2008}
ABSTRACT Background: The influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk. Objective: To conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality. Design: MEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast-cancer-specific death was evaluated by combining multivariable adjusted… 

Dietary fat and breast cancer survival . Dietary fat and breast cancer mortality : A systematic review and meta-analysis

A meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality found the influence of dietary fat remains largely understudied.

Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women's Health Initiative Randomized Trial.

Adoption of a low-fat dietary pattern associated with increased vegetable, fruit, and grain intake, demonstrably achievable by many, may reduce the risk of death as a result of breast cancer in postmenopausal women.

Dietary Factors and Breast Cancer Prognosis among Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies

The main finding was that higher consumption of beer and saturated fat negatively affected BC prognosis, however, the intake of lignans, fiber, multivitamins, and antioxidants was negatively associated with the risk of mortality.

The Impact of Dietary Fat on Breast Cancer Incidence and Survival: A Systematic Review

A systematic review of all the included articles found a significant correlation between dietary fat and an increased risk of breast cancer development and worsening the prognosis for patients already diagnosed with breast cancer.

Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies

This meta-analysis of cohort studies suggested that total fat, SFA, MUFA, and PUFA intake were not associated with the risk of cardiovascular disease, but it was found that higher TFA intake is associated with greater risk of CVDs in a dose-response fashion.

Lifestyle and Breast Cancer

The current evidence linking lifestyle factors and breast cancer incidence and outcome is summarized with emphasis on the findings from full-scale randomized trials and the status of ongoing randomized trials in this area.

Substitution of dietary macronutrients and their sources in association with breast cancer: results from a large-scale case–control study

Replacement of carbohydrates with MUFAs and replacement of dietary carbohydrates with PUFAs might be associated with an increased odds of BC in all participants as well as postmenopausal women, and substitutingMUFAs for carbohydrates, SFAs and PUF as might lower the disease risk.

The Intake of Some Nutrients is Associated with the Risk of Breast Cancer: Results from Jordanian Case-Control Study

The study results demonstrated that increasing the intake of total energy and percentage of fat was significantly and positively associated with BC, and insight was gained of the associations between the total energy intake and some macro/micronutrients intake can be an increasing risk of BC.

Using Genetic Variants to Evaluate the Causal Effect of Plasma Phospholipid Fatty Acids on Breast Cancer and Prostate Cancer: A Mendelian Randomization Study

The evidence is insufficient to support the causal association of the 10 individual plasma phospholipid FAs with breast cancer and prostate cancer.



Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature

Combined estimates of risk for total and saturated fat intake, and for meat intake, all indicate an association between higher intakes and an increased risk of breast cancer.

Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study.

A lifestyle intervention reducing dietary fat intake, with modest influence on body weight, may improve relapse-free survival of breast cancer patients receiving conventional cancer management.

Dietary fat and breast cancer: contributions from a survival trial.

Interim results of the Women’s Intervention Nutrition Study (WINS), a low-fat dietary intervention trial among women diagnosed with breast cancer, suggest a benefit of dietary fat reduction on relapse-free survival and note that adjustment for the surgical procedure did not eliminate the outcome advantage observed.

Physical activity's impact on the association of fat and fiber intake with survival after breast cancer.

Results show that physical activity strongly confounds the association between diet and survival, and animal fat intake and cereal fiber intake was associated with reduced breast cancer death.

Cohort studies of fat intake and the risk of breast cancer--a pooled analysis.

In the context of the Western lifestyle, lowering the total intake of fat in midlife is unlikely to reduce the risk of breast cancer substantially, and there is no evidence of a positive association between total dietary fat intake and the riskof breast cancer.

Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis

There is currently no evidence that weight loss after diagnosis improves survival in newly diagnosed breast cancer patients, and further research should concentrate on assessing whether factors such as diabetes or type of chemotherapy modify the obesity effect and on understanding the causal mechanism.

Dietary fat and breast cancer risk in the Swedish women's lifestyle and health cohort

Type of fat during premenopausal years may have later differential effects on risk, and total fat, MUFA, PUFA or SFA were not associated with risk overall, however, women in the highest MUFA and PUFA quintile intake had a reduced breast cancer risk after age 50 years.

Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies.

A combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women.

Dietary fat consumption and survival among women with breast cancer.

The need for future studies to incorporate clinical and pathologic factors in the analysis, to distinguish between sources of dietary fat intake, and to ascertain dietary patterns subsequent to breast cancer diagnosis was noted.

Dietary Fat, Fiber, Vegetable, and Micronutrients Are Associated With Overall Survival in Postmenopausal Women Diagnosed With Breast Cancer

It is suggested that in postmenopausal women diagnosed with breast cancer, reduced dietary fat and increased fiber, vegetable, fruit, and other nutrient intakes associated with a plant-based, high-fiber diet improves overall survival after breast cancer diagnosis.