Dietary fat and breast cancer metastasis by human tumor xenografts

  title={Dietary fat and breast cancer metastasis by human tumor xenografts},
  author={David P. Rose and Jeanne M. Connolly},
  journal={Breast Cancer Research and Treatment},
Human breast cancer cell lines growing as xenografts in athymic nude mice have been used to examine the effects of dietary fat and fatty acids on tumor progression. The estrogen independent MDA-MB-435 cell line has the advantage that it metastasizes consistently to the lungs and forms quantifiable secondary nodules when injected into the mammary fat pads. With these breast cancer cells, the stimulating effects of polyunsaturated omega-6 fatty acids on both primary tumor growth and metastasis… CONTINUE READING


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