Dietary energy restriction decreases ex vivo spleen prostaglandin E2 synthesis in Emory mice.

Dietary energy restriction prolongs life-span and enhances immune responsiveness by mechanisms yet to be elucidated. Prostaglandin E2 (PGE2) has a suppressive effect on several parameters of cell-mediated immunity. The effect of energy restriction on splenic PGE2 synthesis in Emory mice was studied. Weanling Emory mice were fed an energy-restricted (R, 71.3… CONTINUE READING